Recent advances in severe cutaneous adverse drug reaction
نویسندگان
چکیده
منابع مشابه
Epidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug side effect. This study was designed to investigate the epidemiology and human leukocyte antigen (HLA)-A and -B gene polymorphisms in pediatric patients with SCAR admitted in tertiary referral center, southwestern of Iran from 2013 to 2017. Demographic data, past allergy and autoimmune history, clinical pres...
متن کاملEpidemiology of Severe Cutaneous Adverse Drug Reaction and Its HLA Association among Pediatrics
Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug side effect. This study was designed to investigate the epidemiology and human leukocyte antigen (HLA)-A and -B gene polymorphisms in pediatric patients with SCAR admitted in tertiary referral center, southwestern of Iran from 2013 to 2017. Demographic data, past allergy and autoimmune history, clinical pres...
متن کاملMultiple drug hypersensitivity associated with severe cutaneous adverse reaction
Background Multiple Drug Hypersensitivity (MDH) was first described by Sullivan et al in 1989 as drug allergies to two or more chemically different drugs proven by in-vivo or in-vitro testing. Pichler et al added to this description by suggesting that there are two subtypes of MDH: one where sensitisation to different drug classes may occur simultaneously; the other, sequentially sometimes even...
متن کاملRecent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to lifelong sequelae. Many pharmacogenomic associations in immune and nonimmune related genes with th...
متن کاملA Severe Case of Cutaneous Adverse Drug Reaction Secondary to a Novice Drug: Idelalisib
Phosphatidylinositol 3-kinase δ (PIK3δ) is a tyrosine kinase essential for B cell survival, making it an important target in the treatment of chronic lymphocytic leukemia. Idelalisib is an inhibitor of PIK3δ demonstrating initial success in disease response, but is now shown to have a decreased overall survival and life-threatening serious adverse events. The following is an unfortunate case of...
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ژورنال
عنوان ژورنال: Indian Journal of Dermatology
سال: 2018
ISSN: 0019-5154
DOI: 10.4103/ijd.ijd_591_17